Issue : 01 DOI : 10.5281/zenodo.8147277
INTERNATIONAL
JOURNAL
OF
DIAGNOSTICS
AND
RESEARCH
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
21
Corresponding author: Dr.Patil Ujwala
Article Info: Published on : 15/04/2024
P
ISSN No. : 2584-2757
Volume : 01
Issue : 03
DOI
: 1 0 . 5 2 8 1 / z e n e d o . 1 0 9 7 2 6 0 8
Reg. No. : MAHA-703/16(NAG)
Year of Establishment 2016
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH
Abstract
Cancer is a group of diseases in which there is an abnormal growth of cells that proliferate in an uncontrolled
wa y and in some cases, metastasis (spread) occurs. Cancer is the second most common cause of death in the
Western world, after cardiovascular disease. Established modern treatment includes surgery, chemotherapy
and radiotherapy etc. With varied prognosis and known untoward effects .In Ayurveda, cancer can be co-
related with Granthi (benign or malignant neoplasm) or Arbuda (malignant or major neoplasm). Ayurvedic
treatment includes Dietary regimens, Aushadhi Chikitsa-Dhatwagni Chikitsa, Rasayan Chikitsa, Shodhan
Chikitsa and Agni karma etc. In this research article, we have tried to compile the scattered information
about cancer from various Ayurvedic Samhita, modern text books and published articles.
Keywords: Cancer,Tumor, Arbuda, Granthi,Rasayan Chikitsa.
Review On Integrative Cancer Management
Dr.Dwivedi Amarprakash
1
, Dr.Patil Ujwala
2
1
Professor, Department of Shalyatantra, School of Ayurveda, D. Y .Patil Deemed to be University,Navi Mumbai, India.
2
M.S.(Scholar), Department of Shalyatantra, School of Ayurveda,D. Y.Patil Deemed to be
University, Navi Mumbai,India.
Cite this article as: - Dr.Patil Ujwala (2024) ; Review On Integrative Cancer Management ; Inter.J.Dignostics and Research 1(3)
21-31, DOI:10.5281/zenedo.10972608
Introduction:
Cancer is characterized by uncontrolled
proliferation, tissue invasion, anaplasia and
metastasis. According to estimates, there were
14,61,427 incident cases of cancer in India in 2022
(about 100.4 incidences per 100,000 people).
Cancer is predicted to strike one in nine Indians at
some point in their lifetime. For both men and
women, the most common cancer sites were the
lung and breast, respectively. The most common
type of childhood cancer (014 years old) was
lymphoid leukaemia (29.2% in boys and 24.2% in
girls)
[1].
Cancer occurs because of malfunction of genes
involved in cell proliferation, cell to cell interaction
and those involved in maintaining the integrity of
DNA.
[2]
Pathology-It reveals cellular abnormalities such as
greater number of cells than in normal tissue,
increased size, a higher nuclear to cytoplasmic ratio
and a higher proliferation rate. The cells may
present in abnormal locations or metastasis from
tissue of origin.
[3]
Aetiology Of Cancer
[4]
There are various etiological predisposing factors
responsible for cancer which are listed below in
G
A
R
V
Issue : 03
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
22
Table-1: Various aetiological factors of Cancer
Chemical
Carcinogen
Environmental
carcinogen
Aflatoxin present in food
stuff infected by fungus
Aspergillus causes
hepatocellular carcinoma.
Lifestyle
Smoking
,Tobacco
Lung ,larynx, oral cavity,
oesophagus, kidney,Bladder
and Pancreas cancer
Alcohol
Hepatocellular carcinoma
Salt pickled fish
Nasopharyngeal carcinoma
Occupational
carcinogens
Benzidine & 4-
amino biphenyl
Bladder cancer
Vinyl chloride
Hemangiosarcoma
Drugs
Alkylating
Agents-
Cyclophosphami
de ,nitrosoureas
Acute myeloid leukaemia
Cyclosporin
Non Hodgkin
lymphoma(NHL),Kaposi
sarcoma
Nonsteroidal
estrogen
Vaginal carcinoma, breast
cancer testicular carcinoma
Oral
contraceptives &
tamoxifen
Endometrial carcinoma
Infection
HPV (Human
Papillomavirus)
CA cervix,anal carcinoma &
skin cancer
EBV(Epstein Barr
virus )
Burkitt's Lymphoma ,
nasopharyngeal carcinoma
HBV(Hepatitis B
virus )&HCV
(Hepatitis C
virus)
Hepatocellular carcinoma
H-pylori
Gastric carcinoma
,LYMPHOMA
Schistosoma
haematobium
Bladder cancer
Immunity
Immunosuppressi
on
NHL,Hodgkin's Disease
,Kaposi sarcoma
Radiation
Hereditary
predisposition
Acute and Chronic myeloid
leukaemia, cancer of
lung,bladder,thyroid,bone,sarc
oma of soft tissue,skin cancer
Screening Early detection of cancer is not
possible due its asymptomatic nature in some cases.
So ,before they spread, screening for malignancy is
required. It helps to increase curable rate by loco-
regional treatment alone.
[5]
Table.2. Screening method of different
malignancies
Malignancy
Method of Screening
Breast cancer
Mammography
Cervical cancer
Cervical smear cytology
Prostate cancer
PSA(Serum prostate
specific antigen)
Colorectal cancer
Single flexible
Sigmoidoscopy, Fecal
occult blood test.
Clinical AssessmentThe clinical manifestation
includes both local and systemic features. Local
symptoms are due to the mass effect of local tissue
while systematic symptoms are as a result of
metastases or non metastatic presentation of
malignant disease. During assessment, malignancy
site ,pathology,patient general and systemic
condition (respiratory, cardiovascular), co
morbidity (related with age, tobacco abuse, alcohol
abuse), extent of disease and available treatment is
taken in consideration.
[6]
Local symptoms include pain,lump, skin
abnormality, ulcer etc.Systematic features include
weight loss, fatigue, anorexia, hypocalcaemia,
prothrombic tendency,neuropathies,myopathies,
hormonal effects, etc.
Investigation: Routeing blood investigation,
ultrasound,HIV,HPV,Biopsy(excision,endoscopic,
needle i.e.FNAC), X-ray,Tumour imaging and
sampling by direct vision as Endoscopy
(Sigmoidoscopy , colposcopy smear), CT
scan,MRI, PETscan, Bone scan,Bone marrow.
[7]
Issue : 03
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
23
Immunohistochemistry Markers - S-10,
Cam5.2,CEA (Carcinoembryonic Antigen),CA-
125, ER (Estrogen Receptor, Her-2.
[8]
Tumour markers in blood- CEA, CA-125, AFP
(Alpha Fetoprotein), LDH (Lactate
dehydrogenase),PSA (Prostate specific
antigen),HCG(Human chorionic gonadotropin ).
[9]
TNM ClassificationCancer is staged by the TNM
system [10].T- Extent of primary tumour (T0, T1,
T2, T3-Increases in primary tumour size) N -Extent
of regional lymph node involvement (N1, N2, N3-
Increases in involvement)M-Presence or absence of
metastasis (M0, M1)
Prevention of cancer
[11]
1. Primary Prevention helps to decrease risk of
normal asymptomatic individuals. e.g. Cessation
of smoking for lung cancer.
2. Secondary prevention helps to decrease the
progression of preneoplastic process by
treatment of carcinoma. Early detection of
cancer by special screening method. breast
cancer, carcinoma of cervix etc.
3. Tertiary intervention includes treatment and
chemoprevention of secondary malignancy.
4. Avoid influence of alcohol, tobacco smoking-
chewing, chemical carcinogens etc.
5. Diet should be rich in vegetables and fruits.
Decreasing total fat intake and taking
monounsaturated vegetable fat reduces cancer
risk.E.g. prostate cancer, colorectal carcinoma.
6. Chemoprevention use of drugs for prevention
of cancer.e.g.Beta-carotene shows regression of
leukoplakia.
7. Surgery has a role in patients predisposed to
cancer. e.g. bilateral mastectomy in patients with
familial breast cancer.
Treatment
During management of cancer patients, patients
must be informed about the diagnosis, the stage and
prognosis with treatment options.
1. Excision Most solid cancers are cured with
surgical excision.E.g.breast cancer,lung,colorectal
cancer etc.
[12]
2.Radiotherapy-In radiotherapy, ionizing radiation
done with radiation from a radioactive isotope or by
high energy radiation beams mostly X-ray. There
are 3 methods
Teletherapy- done from a distance by a
linear accelerator
Brach therapy-direct application on to or
into a tumour e.g. head and neck cancer
Intravenous injection of radioisotope
e.g.131-iodine for cancer of thyroid,89-
strontium for bone metastases from prostate
cancer [13].
3.Chemotherapy In chemotherapy, various
cytotoxic agents are used which have intracellular
effects. These drugs are not specially designed to
target malignant cells and also have side effects so
sometimes drugs of different classes are used in
combination.Here,drugs are given intravenously
every 3-4 weeks, about 4 and 8 cycles of treatment
are usually given in total.
[14]
E.g.Alkylating agents- Melphalan,
Cyclophosphamide
Antibiotics Bleomycin, Mytomycin
Antimetabolites-Methotrexate,5-fluorouracil
Mitotic spindle poisons-
Vincristine,Daunorubicin,Etoposide
Miscellaneous-
Cisplatin,Procarbazine,Carboplatin
Combination -
CMF(Cyclophosphamide,methotrexate,5-
fluorouracil
Cisplastin and 5-fluorouracil,Carboplatin
and paclitaxe
4.Hormonal treatmentsIn certain cancer, like
breast cancer, prostate cancer, hormonal therapy
reduces the proliferation of cancer cell and increase
their loss through apoptosis leading to tumour
shrinkage.E.g.Progesterone, Anti oestrogen
(tamoxifen), ovarian ablation, testicular ablation
etc.
[15]
Issue : 03
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
24
5.Biological treatments-
Immunological treatment As the patient
immune system can alter the natural history
of malignancy. Research proved that
interferons are active in melanoma and
lymphoma. They are also beneficial as
adjuvant (after surgery and chemotherapy
respectively). E.g. Rituximab is an antibody
against the common B-cell antigen
CD20.The monoclonal antibody
trastuzumab is effective in advanced breast
cancer.
Biophosphonates-They inhibit osteoclast
function, reduce bone pain, and also prevent
skeletal complications in advanced breast
cancer and myeloma.
[16]
6. Molecular biology develops certain drugs having
potential to target cancer cell more selectively, with
reduced toxicity to normal tissue.
E.g. Gefitinib and imatinib are used in many solid
tumours such as breast and lung cancer.
[17]
Ayurvedic Perspective:
In Ayurveda, according to Charka’ and Sushruta
Samhita’ cancer is described as an inflammatory or
non-inflammatory swelling which mentioned either
as ‘Granthi’ (minor neoplasm) or ‘Arbuda’ (major
neoplasm).
[18]
Acharya Sushruta has well explained Granthi and
Arbuda in Sushruta Samhita. According to
Sushruta, the fundamental cause of major neoplasm
is the pathogens that affect all parts of the body.
Sushruta mentioned the sixth layer of the skin as
Rohini’ (epithelium) and injury to this layer caused
by lifestyle errors, unhealthy foods, poor hygiene
and bad habits results in vitiation of Doshas ,
which leads to the manifestation of tumors.
[19,20]
There are some factors causing vitiation of Doshas .
[21].
a. Stressful Situations, an excessive consumption of
bitter, pungent, astringent, and dry foods are
aggravating factors for Vata Doshas .
b. Extreme consumption of fried, sour, and salty
meals, as well as extreme anger, are also
exacerbating factors for Pitta Doshas .
c. Excessive consumption of sugary, fatty foods and
sedentary lifestyle are aggravating factors for
Kapha Doshas .
d. Excessive consumption of foods high in acid or
alkali constitutes an exacerbating factor for Rakta
Doshas . Sour fruits, wine, fried and roasted food,
alcoholic beverages are a few examples.
e. Excessive consumption of foods high in
exudates, such as meat, fish, yogurt, milk, and
cream, is one of the aggravating causes for Mamsa.
One of the ways that bacteria invade the fatty
tissues is through sedentary behaviors, including
sleeping throughout the day and overeating.
1.Granthi-Benign tumors:
Samprapti (Pathogenesis):
Due to unsalutary lifestyle and food habits, Vata
and other Kapha-related Doshas become
aggravated, vitiate the muscle, blood, and fat tissues
and result in a hard, round swelling known as
Granthi (tumor).
[22]
Lakshana (Signs and symptoms):
Acharya Sushruta described lakshana according to
vitiation of Doshas as follows.
[23]
Table- 3: Lakshana of Granthi according to vitiation
of Doshas .
Types
Cause
Lakshana(Sign and
symptoms)
Vataja
Granthi
Due to
vitiation of
Vata
Doshas .
Swelling is hard, black in
color, enlarged like the
bladder, exudes clear
blood, pain like
cutting,stretching,vibrating.
Pittaj
Granthi
Due to
vitiation of
Pitta
Doshas .
Swelling is red, slightly
yellowish in color, exudes
warm blood in large
quantities, pains such as
burning, very warm
sucking and as burnt by
fire.
Kaphaj
Granthi
Due to
vitiation of
Kapha
Doshas .
Swelling is cold to touch,
not discolored, slight pain
but severe itching, grown
big like a stone, develops
slowly, exudes white thick
pus.
Issue : 03
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
25
Types
Cause
Lakshana(Sign and
symptoms)
Medoja
Granthi
Due to
vitiation of
medas (fat)
Swelling is unctuous, very
big in size, mild pain but
severe itching, exudes fatty
liquid resembling paste of
sesame or ghee.
Siraja
Granthi
In weak
person, due
to
excessive
physical
exercises,
Vata gets
aggravated
Squeezing and
compression of
sira,painless, immobile,
raised circular Granthi.
2.Arbuda -Malignant Tumor/Cancer/Carcinoma
Samprapti (Pathogenesis) :
Due to indulgence of unsalutary food habit, Doshas
get aggravated. These aggravated Doshas cause
vitiation of the muscle tissue and form swelling
which is round, static (immovable), big in size,
deep rooted, growing slowly and not ripening
(forming pus). This is called Arbuda.
[24]
Types of Arbudawith Lakshan:
Vataja, Pittaj, Kaphaj, Raktaj (blood), Mamsaja
(muscles) and Medoja (fat) Arbuda are types of
Arbuda.Their symptoms are similar to
corresponding types of Granthi (benign tumors).
Raktaj Arbuda:
Raktaj Arbuda is formed due to vitiation of Doshas
associated with blood and getting localized in the
veins (blood vessels), producing squeezing and
contraction in them, and giving rise to swelling
which increases in size quickly. It Exudes vitiated
blood continuously.
[25]
Mamsaja Arbuda :
Due to injury to the body part , the muscle gets
vitiated which gives rise stone-like swelling which
is painless, the same color of the body, not forming
pus and non -movable, produces Mamsarbuda. This
Mamsarbuda is incurable.
Sadhya Asadhyata: (Prognosis):
Curable: Vataja, Pittaj, KaphajArbuda may be
considered as Benign tumors. Incurable: Raktaj
=Blood borne , Mamsaja= Sarcoma and Medoja=
Fatty tissues born; these may be considered as
Malignant tumors. Further Arbuda are classified as
per sites of occurrence such as;
Talwarbuda- Tumor occurring in Palatal
region Tumor occurring in Forehead region
Nasaarbuda- Tumor occurring in Nasal
region
Netrarbuda- -Tumor occurring in Eye lid
region
Medhrarbuda- Tumor occurring in Penile
region
Galarbuda-Tumor occurring in Throat
region
Mamsarbuda- Tumor occurring in Muscles
Metastasis: Adhyarbuda and Dwandwarbuda
:Adhya Buda refers to Arbuda that develop in pre-
existing sites, while Dwiarbuda, or metastasis,
refers to many related growth types that occur in
different regions one after the other.
[26]
Other
Malignant diseases: These comprise, in particular,
the pains associated with the Asadhya diagnosis as
well as specific indications that resemble cancer.
Mamsaja Kacchapa, Galaudha, Tridosaja Gulma,
Asadhyata Galaganda, Lingarasa, and Asadhya
Vrana are a few examples of these .
[27]
Mamsaja Ostha: This condition causes constant
pain on the lips, which can sometimes lead to ulcers
and a thick, heavy weight.
Alasa: Due to vitiation of Rakta and Kapha, there is
a profound swelling beneath the tongue's surface. It
resembles epidermoid tumors of salivary glands.
Mamsa Kacchapa: A large swelling of the palate
occurs due to vitiation of Kapha which becomes
painful, grows, and cannot be treated. From the
appearance, it appears to be a hard palate tumor.
Issue : 03
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
26
Galaudha also develops due to the vitiation of
Rakta and Kapha. This disease is characterized by a
massive swelling in the throat that obstructs the
trachea and esophagus, making it fatal for sufferers
to breathe or swallow.
Granthi Chikitsa (Treatment mentioned in
Sushruta Samhita)
In the unripe stage of Granthi (benign tumors), the
treatments indicated for shopha (inflammatory
swelling) is advocated such as Vimlapana,
Avsechan, Upanaha,Shodhana,Ropana etc
.Similarly, different types of lepa application,
medicated decoction are used for treatment
according to vitiation of Doshas .
Table- 4: Granthi Chikitsa mentioned in Sushruta
Samhita
Vataja
Granthi
Chikitsa
Decoction - Dashmoola with sneha
Lepa- Gojiva - Tinospora
cordifolia,Tailapatra (Musali) -
Chlorophytum borivilianum,Rohini
(katukarohini) - Picrorhiza kurroa
Amrita - Tinospora cordifolia ,Bharngi -
Clerodendrum serratum,Shoynaka -
Oroxylum indicum,Bilva - Aegle
marmelos,Aguru - Aquilaria
agallocha,Arka - Calotropis procera,
Aragvadha - Cassia fistula cleaned with
the decoction of bilva, Arkaand
aragvadha.
Healing of wound- Medicated oil
prepared with Rasna, Vidanga,
Yashtimadhuka and kṣira (milk).
[28]
Pittaj
Granthi
Chikitsa
Bloodletting -Application of leeches
Decoction -kakolyadi Vargas with sugar
Lepa-Barks of madhuka, jambu, arjuna
and vetasa
Incision and drainage of pus, cleaning
with decoction of panchvalkala,
Healing-paste of Tila and
Yashtimadhuka.
[29]
Kaphaj
Granthi
Chikitsa
Lepa-Paste of aragvadha, kakananti,
,pindaphala (tikta alabu), arka, bharngi,
karanja, and madana
Excision of ripe tumor
Healing-medicated oil prepared with
viḍanga, patha and rajani.
Medoja
Granthi
Chikitsa
Excision by scraping with a sharp
instrument.
Cleaning with gomutra and a paste of
Tila, suvarachika, haritala
Healing -Karanja, gunja, inguda and
gomutra.
[30]
Arbuda Chikitsa (mentioned in Sushruta
Samhita): Treatment of malignant tumor/
carcinoma
Like Granthi Chikitsa, in Arbuda Chikitsa different
lepa application,decoction, bloodletting excision
etc.have adopted according to vitiation of doshas.
Table- 5: Arbuda Chikitsa mentioned in
Sushruta Samhita
Vataja
Arbuda
Chikitsa
Fomentation Poultice with seeds of
karkaruka, ervaruka, narikela,
priyala
Bloodletting by sucking horn
Decoction of Vata mitigating drugs,
milk and sour liquids (sauviraka etc)
.
[31]
Pittaj
Arbuda
Chikitsa
Sudation done with warm poultices
and mild purgation
Lepa-paste of sarjarasa, priyangu,
pattanga, rodhra, anjana
(srotonjana), aragvadha, gojihva
mixed with honey, decoction of
yastimadhu
[32]
Issue : 03
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
27
Kaphaj
Arbuda
Chikitsa
Excision with caustic alkali, fire
(thermal cautery) and shastra
Bloodletting, cleaning with
decoction of leaves of jati and
karavira.
Healing -medicated oil prepared
with bharingi, viḍanga, patha and
triphala.
[33]
Medoja
Arbuda
Chikitsa
First, fomentation then incision.
Cleaning of wounds with Shodhan
dravya.
Suturing of wounds. Dressing with
Karanja taila with honey.
[34]
Arbuda punarutpatti (Recurrence of
tumors/metastasis) :
Those Arbuda (malignant tumors) in which
remnants of tumor tissue remain, they develop
again quickly; hence they should be excised
without leaving any residue; as any residue left will
kill the patient just like fire.
[35]
Conservative Ayurvedic Therapy for Cancer
management :
Ayurveda plays a very important role in cancer
patients, including curative, palliative, preventive,
and supportive effects. Ayurvedic medications work
through a variety of pharmacokinetic pathways to
enhance patients' quality of life. Roganashani
Chikitsa (disease cure), Rasayan Chikitsa
(restoration of normal function), and Naishthiki
Chikitsa (spiritual approach). Prakritisthapani
Chikitsa are used to maintain the health of cancer
patients [36,37].In Rasayan Chikitsa, drugs which
are used have proved for their antioxidant
properties.Panchakarma procedures (Vaman,
Virechan, Raktamokshana, Nasya, Basti) help to
remove the vitiated doshas from cancer patients. In
debilitated ,weak cancer patients ,Shodhan Chikitsa
is not possible where Shaman Chikitsa has been
used for maintaining health.
Certain Agad formulation is used for treatment of
cancer patient like Vilwadi and Kalyanaka having
radio toxicity protection. Ajithagadam have Nephro
toxicity protection.
[38]
It has been proved that
Snehana, or the traditional use of different
therapeutic oil preparations a week or ten days
before the commencement of chemotherapy or
radiation therapy help to reduce the harmful effects
of such treatments.
[39]
Certain Ayurvedic herbal preparations have been
scientifically proven for their anti-cancer properties.
These preparations not only help in healing but also
reduce the side effects along with complications
associated with cancer patients [40].
E.g. Aloe vera - Aloe barbadensis miller,Berberis
aristata - Berberis aristata,Curcuma longa -
Curcuma longa (Turmeric),Bacopa monnieri -
Bacopa monnieri ,Tagar - Valeriana wallichii
(Indian Valerian),Chitrak - Plumbago
zeylanica,Ashwagandha - Withania somnifera
,Amla (Aamalki) - Phyllanthus emblica ,Bhallatak -
Semecarpus anacardium, Guduchi - Tinospora
cordifolia ,Musta - Cyperus rotundus
(Nutgrass),Pippali - Piper longum (Long
Pepper),Haritaki - Terminalia chebula (Chebulic
Myrobalan).
A combination of Curcuma longa, Ashwagandha -
Withania somnifera, - Tinospora cordifolia, and
Azadirachta indica in the proper ratios and
phytoactive concentrations has proven immuno-
enhancing effect.
[41,42]
It is hypothesized that biological fluids such as
blood, urine, pleural effusions, etc., contain an anti-
cancer agent that can cause regression of cancer and
delay the process of carcinogenesis.
[43,44]
In the view of eight types of urine of animals being
mentioned in Ayurveda, some researchers advocate
Shivambu Chikitsa (auto urine therapy) with
variable claims on result. Similarly, use of cow
urine(Gomutra) therapy for cancer treatment has
also proved beneficial in few research studies as
having no side effects.
[45,46]
Several research
studies have shown the use of mantras, faith,
prayers, and meditation to treat cancer.
[47,48]
These
therapies improve health through mindfulness,
breathing exercises, postures, movements, and
Issue : 03
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
28
relaxation. Further, there is a scope to study
Ayurvedic modalities, including Yoga, langhan and
Panchkarma, for their effects on mitochondria in
cancer. Ayurvedic Chikitsa such as Yukti-
vyapashraya, Sattva-vajaya and Daiva-
vyapashraya also have significant opportunities for
integrative research, management and
complications in cancer
[49,50]
Discussion:
In this review research article, we tried to compile
the information of Cancer from various modern
surgical texts in view of definition,
pathophysiology, signs and symptoms and available
treatment as per stages of disease.We had also well
explained the Ayurvedic perspective of cancer such
as Arbuda, Granthi in relation to its classification,
pathogenesis, sign and symptoms and treatment. In
Modern, various treatment modalities have been
used for cancer such as Chemotherapy, Surgery,
Radiotherapy. In Ayurveda, this treatment can be
correlated with Bheshaj, Shastra, Agni karma
Chikitsa which are well explained by Acharya
Sushruta in Sushruta Samhita. These treatment
modalities are principally like today’s prevalent
treatment of Cancer.This documented information
will help research scholars to understand the
integrated approach towards Cancer management.
Conclusion:
This review article explains the Cancer description
in ancient Ayurvedic as well as modern medical
science. In Ayurveda, Cancer and its symptoms are
classified on the basis of Doshas, Dhatu, tumor site
and treatment is also adopted accordingly. Various
studies have been proved that many of the herbs
like Ashwgandha, Triphala, Shatavari etc. are used
for treatment of various cancers which not only
helps in healing but also reduces side effects of
Chemotherapy and Cancer associated problems.
Ayurvedic treatment also described Shodhan-
Shaman Chikitsa, Panchkarma, Rasayan Chikitsa,
dietary regimen, Agni karma, etc. which plays an
important role in the prevention and minimize the
risk and side effects of therapy and prolong the life
span of cancer patient. Similarly, Ayurvedic
literature also helps to understand the clinical
features of tumor forming cancer in early
stages.Further, more research, clinical study should
be done to identify safe and effective anticancer
drugs in Ayurveda and modern medical science to
prevent the major cause of death of Cancer patients.
References:
1. Krishnan Sathishkumar , Meesha Chaturvedi ,
Priyanka Das , S Stephen , Prashant Mathur
Cancer incidence estimates for 2022 &
projection for 2025: Result from National
Cancer Registry Programme, India. Indian J
Med Res 156, November 2022, p.1
2. Siddharth N.Shah .editors. API Textbook of
Medicine, Oncology, 7th edition. The
Association of Physicians ofIndia; 2003.p.992
3. Nicholas A, Nicky R, Brian R, John A. editors.
Davidson’s Principle and Practice of Medicine.
Oncology, D. A. Cameron ,G.C.W.
Howard,.20thedition, Churchill Livingstone
Elsevier;2006. p.258
4. Siddharth N.Shah. editors.API Textbook of
Medicine, Oncology,7th edition. The
Association of Physiciansof India; 2003.p.
992,993
5. Nicholas A, Nicki R, Brian R, John A. editors.
Davidson’s Principle and Practice of Medicine.
Oncology, D.A. Cameron, G.C.W.
Howard,20th edition, Churchill Livingstone
Elsevier;2006. p.255
Issue : 03
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
29
6. Nicholas A, Nicki R, Brian R, John A. editors.
Davidson’s Principle and Practice of Medicine.
Oncology, D.A. Cameron, G.C.W.
Howard,20th edition, Churchill Livingstone
Elsevier; 2006.p.256,257
7. Nicholas A, Nick R, Brian R, John A. editors.
Davidson’s Principle and Practice of
Medicine. Oncology, D.A. Cameron , G.C.W.
Howard,.20thedition, Churchill Livingstone
Elsevier;2006. p.257
8. Nicholas A, Nicki R, Brian R, John A. editors.
Davidson’s Principle and Practice of Medicine.
Oncology, D.A. Cameron, G.C.W.
Howard,.20thedition,Churchilllivingstone
Elsevier;2006. p.258
9. Nicholas A, NickR,BrianR, JohnA.editors.
Davidson’s Principleand Practice of Medicine.
Oncology, D.A. Cameron, G.C.W.
Howard,.20thedition,Churchilllivingstone
Elsevier;2006. p. 259
10. Nicholas A, Nicki R,Brian R,John A. editors.
Davidson’s Principle and Practice of Medicine.
Oncology,D.A.Cameron,G.C.W.Howard,.20th
edition,Churchilllivingstone Elsevier;2006.
p.259
11. Siddharth N.Shah.editors. API Textbook of
Medicine, Oncology,7
th
edition. The
Association of Physiciansof India ;2003. p.994
12. Nicholas A, Nicki R,Brian R,John A. editors.
Davidson’s Principle and Practice of Medicine.
Oncology, D.A.Cameron, G.C.W.
Howard,.20
th
edition,Churchilllivingstone
Elsevier;2006.p. 263
13. Nicholas A, Nicki R, Brian R, John A .editors.
Davidson’s Principle and Practice of Medicine.
Oncology, D.A. Cameron,
G.C.W.Howard,.20
th
edition,Churchilllivingsto
ne Elsevier;2006. p.264
14. Nicholas A, Nicki R, Brian R, John A. editors.
Davidson’s Principle and Practice of Medicine.
Oncology, D.A. Cameron, G.C.W.
Howard,.20
th
edition, Churchilllivingstone
Elsevier;2006. p.265,266
15. Nicholas A, Nicki R, Brian R, John A.
editors.Davidson’s Principle and Practice of
Medicine. Oncology, D.A. Cameron, G.C.W.
Howard,.20
th
edition, Churchilllivingstone
Elsevier;2006. p.267
16. Nicholas A, Nicki R, Brian R, John A. editors.
Davidson’s Principle and Practice of
Medicine. Oncology, D.A. Cameron, G.C.W.
Howard,.20
th
edition,Churchilllivingstone
Elsevier;2006. p.268
17. Nicholas A, Nicki R, Brian R, John. Editors.
Davidson’s Principle and Practice of Medicine.
Oncology, D.A. Cameron, G.C.W.
Howard,.20
th
edition,Churchilllivingstone
Elsevier;2006. p.269.
Issue : 03
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
30
18. Bhishagratha KL. Sushruta Samhita. Sushruta
Samhita. Varanasi: Choukhamba Orientalia;
1991. [Google Scholar]
19. Bhishagratha KL. Sushruta Samhita. Varanasi:
Choukhamba Orientalia; 1991. [Google
Scholar]
20. Sankaran PS. Swellings. In: Prasad GC, Udupa
KN, editors. Suzutan’s contribution to surgery.
Varanasi: Indological Book House; 1976. p.
99111
21. Sastry JLN. Introduction to oncology, cancer
in Ayurveda. Varanasi:
ChoukhambaOrientalia; 2001. p. 124.
22. Prof. K.R SriKantha M, editor. Sushruta
Samhita, Nidan Sthana, Ch.11, Vol.1,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.532
23. Prof.K.R SriKantha M, editor. Sushruta
Samhita, Nidan Sthana, Ch.11, Vol.1,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.533
24. Prof.K. R SriKantha M, editor. Sushruta
Samhita, Nidan Sthana, Ch.11, Vol.1,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.534
25. Prof.K. R SriKantha M, editor. Sushruta
Samhita, Nidan Sthana, Ch.11, Vol.1,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.535
26. Dr. Krishnadev C.P, Dr. Vivekananda k, Dr.
Krishna T. CONCEPT OF CANCER: AN
AYURVEDIC APPROACH. IJRAR, Vol7 (3);
July 2020.p.714
27. Dr. KrishnadevC.P, Dr. Vivekananda k, Dr.
Krishna T .CONCEPT OF CANCER: AN
AYURVEDIC APPROACH. IJRAR, Vol7 (3);
July 2020.p.713
28. Prof. K. R SriKantha M, editor. Sushruta
Samhita, Chikitsa Sthana, Ch.18, Vol.2,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.172
29. Prof .K. R SriKantha M, editor. Sushruta
Samhita, Chikitsa Sthana, Ch.18, Vol.2,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.173
30. Prof.K .R SriKantha M, editor. Sushruta
Samhita, Chikitsa Sthana, Ch.18, Vol.2,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.173
31. Prof.K .R SriKantha M, editor. Sushruta
Samhita, Chikitsa Sthana, Ch.18, Vol.2,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.177
32. Prof.K .R SriKantha M, editor. Sushruta
Samhita, Chikitsa Sthana, Ch.18, Vol.2,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.178
33. Prof.K. R SriKantha M , editor. Sushruta
Samhita, Chikitsa Sthana, Ch.18, Vol.2,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.178
34. Prof.K. R SriKanthaM, editor. Sushruta
Samhita, Chikitsa Sthana, Ch.18, Vol.2,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.179
35. Prof.K. R SriKantha M, editor. Sushruta
Samhita, Chikitsa Sthana, Ch.18, Vol.2,
2
nd
edition, Varanasi: Choukhamba Orientalia;
2004.p.179
36. Jain Roopesh,Kosta Susmit, Tiwari Archana.
Pharmacognosy Res. Nov-Dec 2010; 2(6):
393394. doi: 10.4103/0974-8490.75463
Issue : 03
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH [ISSN No.: 2584-2757]
Volume : 01
Copyright @ : - Dr. Patil Ujwala Inter. J.Digno. and Research IJDRMSID0015 | ISSN : 2584-2757
31
37. Balachandran P, Govindarajan R. Cancer: An
Ayurvedic perspective. Pharmacol. Res.
2005; 51: 1930. [Pub Med]
38. Sandeep Ahirkar, SonaliChalakh .Scope of
Ayurveda in oncology: AReview.WJPMR,Vol
5(8), 2019.p.99
39. Subha Ganguly.Ayurveda for cancer
therapy.WJPR, Vol.3 (9), 2014.p.1477
40. P Balachandran, R Govindarajan.Cancer-an
Ayurvedicperspective. Pharmacological
Research 51(2005). P.23
41. Paradkar P, Dandekar S, Joshi J, Amonkar A,
Vaidya ADB. Assessment of in vitro - in vivo
antimigratory and anti-angiogenic activity of
Curcuma longa Linn.and Tinospora cordifolia
willd. Extracts in cervical cancer. Int J
Pharmaceut Sci Rev Res 2017; 42:8793.
42. Singh N, Yadav S, Rao AS, Nandal A, Kumar
S, Ganaie SA, Narasihman B. Review on ant
cancerous therapeutic potential of Withania
somnifera (L.) Dunal. J Ethnopharmacol
2021;270. ISSN 0378-8741.
43. Vaidya ADB. Urine therapy in Ayurveda:
ancient insights to modern discoveries for
cancer regression. J Ayurveda Integr Med
2018; 9:2214.
44. Vaidya ADB, Amonkar AJ, Bhatt NS, Parikh
PM. Complementary and alternative medicine
for cancer care in India: basic and clinical
perspective. In: AlaouiJamali M, editor.
Alternative and complementary therapies for
cancer: integrative approaches and discovery
of conventional drugs. Boston, MA: Springer
US; 2010. p. 3182
45. Wu D, Fan Y, Liu S, Woollam MD, Sun X,
Murao E, Zha R, Prakash R, Park C, Siegel
AP, Liu J, Agarwal M, Li BY, Yokota H.
Loading-induced antitumor capability of
murine and human urine. Faseb J 2020;
34:757892.
46. Nedelcu AM. The evolution of multicellularity
and cancer: views and paradigms. Biochem
Soc Trans 2020; 48:150518
47. Rao SR, Viswanath V, Srinagesh S. Spiritual
healing in cancer care: a Hindu perspective. In:
Michel, Berher Ann, editors. Global
perspectives in cancer care: religion,
spirituality, and cultural diversity in health and
healing. Oxford University Press; 1922
48. Shihl JA, Moczynski W, Gallivan K, et al. If it
weren’t for my faith”: spirituality in advanced
cancer. Ann Palliat Med 2019; 8:75876.
49. Vyas KM, Dwivedi RR. Role of sattvavajaya
Chikitsa (trance therapy) in the management of
manasa-dosha ajeerna. Ayu 2012; 33:7884.
50. Veena PV, Ausha B, Vaidya SM. Application
of Daiva-vyapashraya Chikitsa in
charakasamhita. Rguhs J Ayush Sci 2019;
6:468.
ISSN : 2584-2757
DOI : 10.5281/zenedo.10972608
Dr. Patil Ujwala Inter. J.Digno. and Research
This work is licensed under Creative
Commons Attribution 4.0 License
Submission Link : http://www.ijdrindia.com
Benefits of Publishing with us
Fast peer review process
Global archiving of the articles
Unrestricted open online access
Author retains copyright
Unique DOI for all articles
https://ijdrindia.com